To be honest quite a few apps don't seem to play nicely without the Intel-specific instructions present. REAPER won't run at all, Cubase crashes unless you remove the surround panner VST, Pro Tools would crash on launch last time I tried it (but this may have been fixed since)...

Unity wont bake lights on Ryzen Hackintosh too using Progressive GPU/CPU. Also VMWare won't run because of lack of Intel specific VT-x support, same with Docker for mac, Virtualbox runs fine though (it finds amd-v).